Research progress of intestinal microorganisms and pathogenesis of diabetes mellitus
10.19485/j.cnki.issn2096-5087.2022.03.008
- Author:
Yuan FANG
;
Xiaoqin HA
- Publication Type:Journal Article
- Keywords:
intestinal microorganism;
diabetes mellitus;
short-chain fatty acid;
bile acid;
lipopolysaccharide
- From:
Journal of Preventive Medicine
2022;34(3):253-257
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:As the largest human microecosystem, intestinal microorganisms participate in human material and energy metabolisms and pose a significant impact on human health. Diabetes mellitus is likely to cause imbalance of abundance and component alterations in intestinal microorganisms, and reduce the diversity and balance, leading to intestinal microflora dysregulation. It has been shown that intestinal microflora dysregulation may promote diabetes development and progression through the reduction of intestinal microbial metabolites, inflammatory reaction and insulin resistance. This review summarizes the involvement of intestinal microorganisms in the pathogenesis of diabetes through metabolites including short-chain fatty acid, bile acid and lipopolysaccharide, and describes the current status of intestinal microorganisms-mediated treatments for diabetes, so as to provide the theoretical basis for the researches on diabetes and intestinal microorganisms.
- Full text:肠道微生物与糖尿病病理机制研究进展.pdf
