Indexes of Suspicion of Typical Cow's Milk Protein-Induced Enterocolitis.
10.3346/jkms.2007.22.6.993
- Author:
Jin Bok HWANG
1
;
Sung Hyuk LEE
;
Yu Na KANG
;
Sang Pyo KIM
;
Seong Il SUH
;
Sin KAM
Author Information
1. Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea. pedgi@korea.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Cow's Milk Protein-Induced Enterocolitis;
Index of Suspicion
- MeSH:
Acidosis/etiology;
Animals;
Cattle;
Enterocolitis/*diagnosis/etiology;
Female;
Humans;
Infant;
Infant, Newborn;
Leukocyte Count;
Logistic Models;
Male;
Methemoglobinemia/etiology;
Milk Hypersensitivity/*diagnosis;
Milk Proteins/*immunology;
Serum Albumin/analysis;
Weight Gain
- From:Journal of Korean Medical Science
2007;22(6):993-997
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was performed to identify clinical factors that facilitate the diagnosis of typical cow's milk protein-induced enterocolitis (CMPIE). Data from 142 consecutive patients (aged 15 to 45 days, cow's milk formula- or cow's milk and breast milk mixed-fed) admitted due to vomiting and/or diarrhea were retrospectively analyzed. These 142 subjects were divided into three groups: the CMPIE, infection, and non-infection group. Each group was composed of 16 (11.3%), 102 (71.8%), and 24 (16.9%) patients, respectively. On admission, poor weight gain (p=0.003), hypoalbuminemia (p=0.035), peripheral leukocytosis (p=0.012), and metabolic acidosis (p=0.015) were found to be more significant in the CMPIE group than those in other two groups. In CMPIE, serum albumin levels decreased from 3.3+/-0.9 g/dL on admission to 2.6+/-0.3 g/dL during admission (p<0.05), and methemoglobinemia was observed in 3 patients (18.8%) (p=0.012). Multiple logistic regression analysis showed that the independent predictors of CMPIE versus the infection group were failure to gain weight (OR, 10.75 [95% CI, 1.53-66.12]) (p= 0.014) and hypoalbuminemia (OR, 9.53 [95% CI, 1.62-49.01]) (p=0.010). The early recognition of indexes of suspicion for CMPIE may be of help in the diagnosis and treatment of this disorder.
