Reconstruction and Biomechanical Design of Microvascular Models
10.16156/j.1004-7220.2022.01.28
- VernacularTitle:微血管模型的重建和生物力学设计
- Author:
Ping ZHAO
1
;
Xiao LIU
1
;
Haoran SU
1
;
Xing ZHANG
1
;
Yubo FAN
1
;
Xiaoyan DENG
1
Author Information
1. Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang Universit
- Publication Type:Journal Article
- Keywords:
microfluidic;
vascular models;
biomechanical microenvironment
- From:
Journal of Medical Biomechanics
2022;37(1):E180-E185
- CountryChina
- Language:Chinese
-
Abstract:
Neovascularization plays an important role in many physiological and pathological processes, but its mechanism is still unclear. Since vascular cells are subjected to a variety of biochemical and biomechanical stimulations in vivo and live in a complex microenvironment, it is necessary to construct the vascular model in vitro and simulate the in vivo microenvironment to explore the mechanism of neovascularization. Recently, owing to the advance of micromachining and microfluidic technology, various in vitro microvascular models have emerged. Variables such as shear stress, interstitial flow and biochemical gradient of angiogenic factors have been controlled in these models, which greatly promotes the research of neovascularization. The construction, development and biomechanical design of various microvascular models are reviewed in this paper.
