Deeper Understanding the Pathogenesis of Osteoarthritis from Matrix Viscoelasticity and Calcium Signaling
10.16156/j.1004-7220.2022.01.01
- VernacularTitle:从基质黏弹性和钙信号深入理解骨性关节炎发病机制
- Author:
Quanyou ZHANG
1
;
Weiyi CHEN
1
Author Information
1. College of Biomedical Engineering, Taiyuan University of Technology
- Publication Type:Journal Article
- Keywords:
osteoarthritis (OA);
chondrocyte;
matrix viscoelasticity;
calcium signaling;
mechanosensitive ion channel
- From:
Journal of Medical Biomechanics
2022;37(1):E001-E003
- CountryChina
- Language:Chinese
-
Abstract:
Generally, extracellular matrix (ECM) has the characteristics of viscoelasticity. In osteoarthritis (OA), catabolic processes alter the viscoelastic properties of functional pericellular matrix (PCM) of chondrocytes. Chondrocytes sense and respond to their mechanical microenvironment via an array of mechanosensitive receptors and channels that activate a complex network of downstream signaling pathways to regulate several cell processes central to OA pathology. Advances in understanding the specific mechanosignalling mechanisms in articular cartilage will promote the development of cell microenvironment construction in cartilage tissue engineering and the targeted precision therapeutics for OA. In this review, the work on the mechanism of matrix viscoelasticity regulating chondrocytes mechanotransduction by Agarwal et al. was briefly commented, and the recent advances related with their work was also discussed.
