Suppressive effect of lignans from Euphorbia neriifolia L.on esophageal squamous cancer cell
10.11665/j.issn.1000-5048.20220114
- VernacularTitle:金刚纂中木脂素对食管鳞癌细胞的抑制作用
- Author:
Weiyan QI
;
Chunlei XIA
;
Roujin AN
;
Xinmei Gao
;
Dongping LI
;
Hanmei XU
- Publication Type:Journal Article
- Keywords:
Euphorbia neriifolia L.;
lignans;
antitumor activity;
cell apoptosis
- From:
Journal of China Pharmaceutical University
2022;53(1):93-98
- CountryChina
- Language:Chinese
-
Abstract:
Eubhorbia neriifolia L. is a plant of Euphorbia family.Five known lignans were isolated from the aerial parts of E. neriifolia L. by silica gel for column chromatography and preparative high-performance liquid chromatography (HPLC).Their potential antitumor activities were evaluated in vitro.Compound 2 exhibited proliferation inhibition and cytotoxicity against esophageal squamous cancer cells, especially KYSE-410 and KYSE-450 cells.Further analyses showed that compound 2 could significantly induce apoptosis through the activation of caspase 3/9 and down-regulation of the Bcl-2/Bax protein ratio.These results suggested that compound 2 had a significant inhibitory effect on the esophageal squamous cancer cells, especially KYSE-410, which deserves further research as a potential antitumor agent.
