Applications of functional genomics in research of benzo[a]pyrenetoxicity：a review
10.19485/j.cnki.issn2096-5087.2022.02.009
- Author:
Bin CAO
;
Yanhua SONG
- Publication Type:Journal Article
- Keywords:
B[a]P；genome expression regulation；functional genomics；bioinformatics
- From:
Journal of Preventive Medicine
2022;34(2):151-155
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Benzo [a] pyrene ( B [a] P ) is a well-recognized environmental pollutant. Exposure to B[a]P elicits many adverse biological effects, including tumorigenesis, immunosuppression, teratogenicity, and hormonal effects. In addition to B [a] P exposure-induced genetic damages, a growing number of studies demonstrate that epigenetic changes play an important role in chemically induced carcinogenesis. In order to provide better understanding of epigenetic changes of B [a] P and their potential association with genotoxic endpoints, this review summarizes the advances in the applications of functional genomics in the research of B [a] P toxicity, including functional genomics techniques, regulation of human genome expression, DNA sequence variability, model organisms research, and bioinformatics studies, so as to provide insights into the management of B [a] P exposure-induced health injuries and use of genomics techniques to unravel the mechanisms underlying the toxicity of other environmental pollutants.
- Full text:功能基因组学在苯并[a]芘毒性研究中的应用进展.pdf
