Clinical analysis of 21 cases of IgG4-related diseases
10.12016/j.issn.2096-1456.2022.04.005
- Author:
ZHANG Qi
1
;
NAN Xinrong
2
;
YAN Xingquan
3
;
ZHANG Zejun
1
;
ZHAO Jiaxiong
1
;
REN Xiaoyan
1
Author Information
1. School of Stomatology, School of Stomatology, Shanxi Medical University
2. 1.School of Stomatology, School of Stomatology, Shanxi Medical University 2.Department of Stomatology, the First Hospital, Shanxi Medical University
3. Department of Stomatology, the First Hospital, Shanxi Medical University
- Publication Type:Journal Article
- Keywords:
IgG4-related diseases;
parotid gland;
submandibular gland;
lacrimal gland;
pancreas;
IgG4;
plasma cells;
lymphocyte;
head and neck;
glucocorticoid
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2022;30(4):258-265
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To summarize the clinical manifestations of IgG4-related diseases in the head and neck, explore treatment methods.
Methods :The clinical data of 21 patients diagnosed with IgG4-related diseases were retrospectively analyzed. The clinical data and the results of glucocorticoid and immunosuppressive therapy were studied retrospectively.
Results:All patients had swollen sclerotic masses, and CT showed irregular high-density masses with uniform enhancement in the enlarged glands. Some patients had mucosal thickening and mass-like changes in theoral cavity, nose, sinuses, throat and other tissues, and most of the patients had cervical lymphadenopathy and elevated serum IgG4 levels (≥ 1.35 g/L). Histopathological examination of affected exosine glands and affected mucosa and lymph nodes in all patients showed infiltration of lymphocytes, plasma cells and IgG4+ plasma cells. In 21 patients, the mass in the affected glands and mucosa (including head, neck and other tissues) disappeared, and the clinical symptoms were relieved after the application of glucocorticoids. However, with a reduction in glucocorticoids, the mass recurred or even worsened.
Conclusion :For patients with a single mass in the submandibular gland, parotid gland and other salivary glands, as well as lymph node enlargement, CT is the first choice to identify the nature of gland neoplasms. Combined with pathological examination, related auxiliary examination and peripheral blood examination are also needed to obtain a definitive diagnosis. Glucocorticoid therapy is used to achieve a good prognosis, and long-term follow-up and timely adjustment of medication regimens are required.
- Full text:IgG4相关疾病21例临床分析.pdf
