Research progress of endothelial-to-mesenchymal transition in ocular diseases
10.3980/j.issn.1672-5123.2022.3.15
- VernacularTitle:内皮-间质转化在眼部疾病中的研究进展
- Author:
Zhi-Shang Meng
1
Author Information
1. 1Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China|2Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
- Publication Type:Review
- Keywords:
endothelial-mesenchymal transition;
ocular diseases;
TGF-β;
fibrosis
- From:
International Eye Science
2022;22(3):425-428
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial-to-mesenchymal transition(EndoMT)is a change in the transformation or differentiation of endothelial cells into mesenchymal cells under physiological or pathological conditions, accompanied by changes in phenotype and function, and is an important part of fiber repair. It is widely involved in the pathophysiological process of embryonic development, tumor invasion and a variety of fibrotic diseases. Research on the role of EndoMT in ocular diseases has also made some progress. This article will review the basic biological characteristics, mechanism and research results of EndoMT in ophthalmological diseases, intending to theoretically reveal its possibility as a treatment target and a key point of regenerative medicine technology in related diseases, provide a reference for clinical practice and scientific research.
- Full text:202203015.pdf
