Clinical characteristics and changes of serum tumor markers in lung cancer patients with different smoking in Hanzhong
10.3969/j.issn.1006-2483.2022.01.032
- VernacularTitle:陕西汉中地区不同吸烟肺癌患者临床特点及血清肿瘤标志物水平变化
- Author:
Li LIU
1
;
Jun ZHANG
1
;
Ting LI
1
;
Zhengfu CHEN
2
Author Information
1. Department of Laboratory Medicine , 321 Hospital of Hanzhong City , Hanzhong , Shaanxi 723000 , China
2. Department of Nuclear Medicine, 321 Hospital of Hanzhong City , Hanzhong , Shaanxi 723000 , China
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Serum tumor markers;
Different smoking status;
Clinical features
- From:
Journal of Public Health and Preventive Medicine
2022;33(1):146-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics and changes of serum tumor markers in lung cancer patients with different smoking status in Hanzhong area. Methods A retrospective analysis was performed on 642 hospitalized lung cancer patients in Hanzhong area from March 2017 to March 2019. According to their smoking status, they were divided into observation group (smoking history, n=404) and control group (no smoking history, n=238). Age, sex, place of residence, basic information of the disease including pathological stage, pathological type, short-term efficacy, survival and serum tumor marker level were analyzed retrospectively. Results The proportion of male in observation group (67.08%) was significantly higher(57.56%) (χ2=5.855,P<0.05). Observed a group of 50 or more patients (80.94%) were significantly higher (73.53%) (χ2=4.824 , P<0.05); There was no significant difference between the two groups (χ2=2.110 , P<0.05). The proportion of adenocarcinoma in the control group (49.16%) was the highest, and that of small cell lung cancer in the observation group (41.34%) was the highest (χ2=15.291, P <0.05). Comparison of pathological stages between the two groups showed that stage IIIB (32.77%) was the highest in the control group, followed by stage IV (23.53%), Stage IIIA (20.59%), Stage II (13.03%) and stage I (10.08%). The observation group had the highest proportion in stage IIIA (35.40%), followed by Stage IIIB (25.00%), stage IV (16.09%), Stage IIIA (16.09%), stage II (15.10%) and stage I (8.42%). The difference between the two groups was statistically significant (χ2=10.817,P<0.05). Before treatment, serum CEA, CA125 and CA199 levels in observation group were significantly higher (P<0.05). After treatment, the levels of serum tumor markers in both groups were significantly decreased (P<0.05); The serum CEA, CA125 and CA199 levels in observation group were significantly higher (P<0.05). After treatment, THE ORR of the observation group (48.76%) was lower than that of the control group (53.78%), but the difference was not statistically significant (χ2=2.051, P>0.05). The 1-year survival rate of the observation group (64.85%) was significantly lower than that of the control group (73.95%) (χ2=5.255, P<0.05). Conclusion Middle-aged and elderly male smokers in Hanzhong area have a high incidence of lung cancer, multiple stage Ⅲ squamous cell carcinoma, and the level of tumor markers in serum is higher than that of non-smokers. The prognosis is not good, so we should encourage patients to quit smoking, which can improve the survival rate of patients.
