Research progress of miR-200 family and obesity-related hypertension
10.3969/j.issn.1006-2483.2022.01.026
- VernacularTitle:MiR-200家族与肥胖相关高血压的研究进展
- Author:
Chuanfei ZHOU
1
;
Dongming WANG
2
;
Weihong CHEN
2
;
Xiaokang ZHANG
1
Author Information
1. Key Laboratory of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical College , Ganzhou , Jiangxi 341000 , China
2. State Key Laboratory of Environmental Protection and Health, Ministry of Education, Department of Labor Health and Environmental Hygiene , School of Public Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030 , China
- Publication Type:Journal Article
- Keywords:
miR-200 family;
Fat;
Obesity-related hypertension
- From:
Journal of Public Health and Preventive Medicine
2022;33(1):120-123
- CountryChina
- Language:Chinese
-
Abstract:
Obesity-related hypertension is a common hypertension as well as a common chronic disease with wide distribution and great harm to human health. In recent years, this disease has become one of the hot issues of public health due to the significant increase in prevalence. The pathogenesis and pathway of obesity-related hypertension are not yet clear, and the research on its pathogenesis has received extensive attention. Studies have shown that they are regulated in most biological processes, including differentiation, proliferation, migration, and apoptosis. The miR-200 family is a group of miRNAs, which have been suggested to play a crucial role in obesity-related hypertension and glucolipid metabolism dysfunction in recent years. This paper reviews relevant research results, suggesting that the expression level of miR-200 family in obese patients with hypertension is higher than that in healthy people, which regulates the occurrence and development of hypertension through mediating oxidative stress response and GATA expression level. This review reveals the relationship between miR-200 family and obesity-related hypertension, which offers new clues to explore potential therapeutic targets for obesity-related hypertension.
