Epithelioid Variant of High-Grade Myxofibrosarcoma in the False Vocal Fold: A Case Report
10.3342/kjorl-hns.2021.00269
- Author:
Seulki SONG
1
;
Dae Hyun SONG
;
Jin Pyeong KIM
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea
- Publication Type:Case Report
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2021;64(12):954-958
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Myxofibrosarcoma (MFS) is a histologic subtype of malignant fibrous histiocytoma (MFH), with a predominant myxoid component. MFS is characterized by locally aggressive behavior and a high rate of local recurrence, however, with a good prognosis. Head and neck MFS accounts for 3% of all cases of MFS. To date, only two cases of laryngeal MFS have been reported. Owing to the rarity of MFS, the clinical characteristics and optimal treatment options remain controversial. Surgical resection with a clear margin is considered the treatment of choice. Compared to traditional MFS tumors, epithelioid variants have worse prognosis. Other factors associated with a poor prognosis of MFS tumors include inadequate surgical margins, large tumor size, old age, and high-grade tumors. Herein, we report a case of high-grade epithelioid variant MFS located in the false vocal fold, requiring total laryngectomy to obtain an adequate surgical margin. To our knowledge, this is the first case report of epithelioid variant of high-grade MFS presenting in the larynx.
