Impact of the Preoperative Neutrophil to Lymphocyte Ratio on Patients with Head and Neck Cancer
10.3342/kjorl-hns.2018.00605
- Author:
Geun-Jeon KIM
1
;
Jun-Myung KANG
;
Jae-Hyun SEO
;
Se-Hwan HWANG
;
Ho-Young YOUN
;
Ho-Jun JIN
;
Ha-Ram KANG
;
Hyun-Ho LEE
;
Young-Hoon JOO
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea
- Publication Type:Original Article
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2020;63(1):26-30
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Background and Objectives:To investigate the prognostic value of the neutrophil to lymphocyte ratio (NLR) in patients with head and neck squamous cell cancer (HNSCC).Subjects and Method Clinical data from 259 patients with HNSCC were collected retrospectively. NLR was adopted as potential prognostic biomarkers.
Results:NLR was associated with cancer recurrence (p=0.002 and p＜0.001, respectively). Patients with a NLR ＞2.15 had significantly decreased 5-year disease specific survival (DSS) based on the Kaplan-Meier survival curves (p＜0.001 and p=0.029, respectively). The Multivariate Cox regression analysis confirmed a significant association between 5-year DSS and the NLR (using 2.15 as the cut-off; hazard ratio, 1.852; 95% confidence interval, 1.237-2.771; p= 0.003).
Conclusion:A NLR cut-off value ≥2.15 was associated with adverse outcomes in patients with HNSCC.
