Steroid Responsive Recurrent Limbic Encephalitis Associated With LGI1 Antibodies.
- Author:
Kyung Ha NOH
1
;
Seung Joo KIM
;
Jae Wook CHO
;
Jin Hong SHIN
;
Jae Hyeok LEE
Author Information
1. Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. jhlee.neuro@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
LGI1 encephalitis;
Limbic encephalitis
- MeSH:
Antibodies*;
Dihydroergotamine;
Female;
Glioma;
Humans;
Inflammation;
Limbic Encephalitis*;
Memory, Episodic;
Memory, Short-Term;
Middle Aged;
Potassium Channels, Voltage-Gated;
Seizures;
Temporal Lobe
- From:Journal of the Korean Neurological Association
2014;32(2):91-94
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histological evidence of mesial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI1) is the autoantigen associated with limbic encephalitis that was previously attributed to voltage-gated potassium channels. We report herein a 54-year-old female with LGI1-related limbic encephalitis who presented with recurrent episodes of episodic memory impairment, depressive mood, and phantosmia. Her symptoms dramatically improved with steroid therapy.
