Logopenic Progressive Aphasia Revealing Positive Cerebrospinal Fluid Biomarkers for Alzheimer's Disease.
- Author:
Hyung Jun KIM
1
;
Tae Eun KIM
;
Saeromi KIM
;
Won Seok CHAE
;
Sun Ah PARK
Author Information
1. Department of Neurology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. sapark@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Biomarker;
Cerebrospinal fluid;
Logopenic aphasia
- MeSH:
Alzheimer Disease*;
Aphasia*;
Aphasia, Primary Progressive;
Biomarkers*;
Cerebrospinal Fluid*;
Diagnosis, Differential;
Female;
Follow-Up Studies;
Humans;
Semantics
- From:Journal of the Korean Neurological Association
2014;32(2):98-102
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary progressive aphasia (PPA) is classified into agrammatic, semantic, and logopenic variants, but differential diagnosis is often challenging. There is accumulating evidence that the neuropathology of logopenic PPA is distinct from that of the other types. We report herein a woman with logopenic PPA who was diagnosed by clinical, neuropsychological, and radiologic data during 2 years of follow-up. Interestingly, her cerebrospinal fluid biomarkers were found to be similar to those found in Alzheimer's disease, with a decreased concentration of Abeta42 and an increased concentration of pTau181 (tTau).
