Risk Factors for Local Tumor Recurrence after Segmental Transarterial Chemoembolization for Hepatocellular Carcinoma: the Importance of Tumor Located in the Segmental Border Zone.
- Author:
Yun Ku CHO
1
;
Jin Wook CHUNG
;
Yong Sik AHN
;
Yoon Ok PARK
;
Jae Kyun KIM
;
Jong Hoon BYUN
Author Information
- Publication Type:Original Article
- Keywords: Liver neoplasms, therapy; chemoembolization
- MeSH: Risk Factors; Retrospective Studies; Proportional Hazards Models; Neoplasm Recurrence, Local; Middle Aged; Male; Liver Neoplasms/*pathology/*therapy; Iodized Oil/administration & dosage; Humans; Female; Doxorubicin/administration & dosage; Chi-Square Distribution; *Chemoembolization, Therapeutic; Carcinoma, Hepatocellular/*pathology/*therapy; Aged; Adult
- From:Korean Journal of Radiology 2006;7(4):267-274
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: We wanted to evaluate whether tumors located in a segmental border zone are predisposed to local recurrence after performing segmental transarterial chemoembolization for hepatocellular carcinoma. MATERIALS AND METHODS: Seventy-three hepatocellular carcinoma nodules were retrospectively analyzed for local tumor recurrence after performing segmental transarterial chemoembolization by using follow-up CT studies (median follow-up period: 20 months, range: 4-77 months). The tumors were divided into two groups according to whether the lesions were located at the segmental border zone (Group I) or not (Group II). Comparison of the tumor characteristics and chemoembolization methods between the two groups was performed using the chi-square test. The local recurrence rates were compared by Kaplan-Meyer method and analyzed with the log rank test. RESULTS: Local tumor recurrence occurred for 25 hepatocellular carcinoma nodules (42.9%). The follow-up periods, tumor characteristics and chemoembolization methods between Groups l and ll were comparable. The local recurrence rate was 64.0% (16/25) in Group I and 18.8% (9/48) in Group II. The difference was statistically significant on the univariate and multivariate analyses (p = 0.000 for both). CONCLUSION: Tumor location in a segmental border zone was a significant risk factor for local tumor recurrence after performing segmental transarterial chemoembolization for hepatocellular carcinoma.
