A Profile of Glucose-6-Phosphate Dehydrogenase Variants and Deficiency of Multicultural Families in Korea
10.3347/kjp.2021.59.5.447
- Author:
Young Yil BAHK
1
;
Seong Kyu AHN
;
Jinyoung LEE
;
Jae Hyoung IM
;
Joon-Sup YEOM
;
Sookkyung PARK
;
Jeongran KWON
;
Hyesu KAN
;
Miyoung KIM
;
Woori JANG
;
Tong-Soo KIM
Author Information
1. Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 27478, Korea
- Publication Type:Original Article
- From:The Korean Journal of Parasitology
2021;59(5):447-455
- CountryRepublic of Korea
- Language:English
-
Abstract:
Vivax malaria incidence in Korea is now decreased and showing a low plateau. Nowadays, vivax malaria in Korea is expected to be successfully eliminated with anti-malaria chemotherapy, primaquine, and vector control. The glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with potential hemolytic anemia after primaquine administration. This inborn disorder has a pivotal polymorphism with genetic variants and is the most prevalent X-chromosome-linked disorder. The prevalence of G6PD deficiency was previously reported negligible in Korea. As the population of multicultural families pertaining marriage immigrants and their adolescents increases, it is necessary to check G6PD deficiency for them prior to primaquine treatment for vivax malaria. The prevalence of G6PD variants and G6PD deficiency in multicultural families was performed in 7 counties and 2 cities of Jeollanam-do (Province), Gyeonggi-do, and Gangwon-do. A total of 733 blood samples of multicultural family participants were subjected to test the phenotypic and genetic G6PD deficiency status using G6PD enzyme activity quantitation kit and PCR-based G6PD genotyping kit. The G6PD phenotypic deficiency was observed in 7.8% of male adolescent participants and 3.2% of materfamilias population. Based on the PCR-based genotyping, we observed total 35 participants carrying the mutated alleles. It is proposed that primaquine prescription should seriously be considered prior to malaria treatment.
