HFA-PEFF scores: prognostic value in heart failure with preserved left ventricular ejection fraction
- Author:
Koichi EGASHIRA
1
;
Daisuke SUETA
;
Takashi KOMORITA
;
Eiichiro YAMAMOTO
;
Hiroki USUKU
;
Takanori TOKITSU
;
Koichiro FUJISUE
;
Taiki NISHIHARA
;
Fumi OIKE
;
Masafumi TAKAE
;
Shinsuke HANATANI
;
Seiji TAKASHIO
;
Miwa ITO
;
Kenshi YAMANAGA
;
Satoshi ARAKI
;
Hirofumi SOEJIMA
;
Koichi KAIKITA
;
Kenichi MATSUSHITA
;
Kenichi TSUJITA
Author Information
- Publication Type:2
- From:The Korean Journal of Internal Medicine 2022;37(1):96-108
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:The Heart Failure Association (HFA)-PEFF score is recognized as a simple method to diagnose heart failure (HF) with preserved ejection fraction (HFpEF). This study aimed to evaluate the relationship between HFA-PEFF scores and cardiovascular outcomes in HFpEF patients.
Methods:A total of 502 consecutive HFpEF patients were prospectively observed for up to 1,500 days. Cardiovascular outcomes were compared between two groups of patients, defined by their HFA-PEFF scores: those who scored 2–4 (the intermediate-score group) and those who scored 5–6 group (the high-score group). Overall, 236 cardiovascular events were observed during the follow-up period (median, 1,159 days).
Results:Kaplan-Meier analysis showed that there were significant differences in composite cardiovascular events and HF-related events between the intermediate-score group and the high-score group (p = 0.003 and p < 0.001, respectively). Multivariate Cox proportional hazards analysis showed that the HFA-PEFF scores significantly predicted future HF-related events (hazard ratio, 1.66; 95% confidence interval [CI], 1.11 to 2.50; p = 0.014); receiver operating characteristic analysis confirmed this relationship (area under the curve, 0.633; 95% CI, 0.574 to 0.692; p < 0.001). The cutoff HFA-PEFF score for the identification of HF-related events was 4.5. Decision curve analysis revealed that combining the HFA-PEFF score with conventional prognostic factors improved the prediction of HF-related events.
Conclusions:HFA-PEFF scores may be useful for predicting HF-related events in HFpEF patients.
