Evaluation of high resolution computed tomography findings of cystic fibrosis
- Author:
Ayse Senay SASIHUSEYINOGLU
1
;
Derya Ufuk ALTıNTAş
;
Sureyya SOYUPAK
;
Dilek DOGRUEL
;
Mustafa YıLMAZ
;
Mahir SERBES
;
Gulsah DUYULER
Author Information
- Publication Type:Original Article
- From:The Korean Journal of Internal Medicine 2019;34(2):335-343
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS:Morphological changes due to lung disease in patients with cystic fibrosis (CF) were evaluated using high resolution computed tomography (HRCT), and the HRCT scores obtained using the Bhalla scoring system were correlated with those obtained using clinical and laboratory indicators.
METHODS:Medical records of 28 children with CF who underwent chest CT in Department of Pediatric Allergy and Immunology, Cukurova University Balcali Hospital between March 2011 and January 2016 were retrospectively reviewed. Demographic data and physical examination, respiratory cultures, pulmonary function tests, and chest HRCT findings were evaluated. Patients were divided into the following two groups according to their forced expiratory volume in the first second (FEVâ‚) values: normal FEVâ‚ (≥ 80% of predicted values) and low FEVâ‚ ( < 80% of predicted values). Deep throat or sputum cultures were evaluated for the presence of Pseudomonas aeruginosa (PsA) and other bacteria. HRCT scans were scored using the Bhalla scoring system.
RESULTS:No significant correlation was found between the Bhalla scores and sex, age group, or height percentiles. Significant relationships were found between the Bhalla score and weight (p = 0.036) and body mass index (BMI) (p = 0.032) percentiles below the third percentile, bacterial growth in the sputum/deep throat cultures (p = 0.009), and presence of PsA (p = 0.004). Moreover, a significant correlation was found between the Bhalla score and FEV₠(r = −0.315, p = 0.0272), forced vital capacity (FVC; r = −0.381, p = 0.0178), forced expiratory flow between 25% and 75% of FVC (r = −0.229, p = 0.0431), and BMI (r = −3.368, p = 0.050).
CONCLUSIONS:Chest HRCT is an important diagnostic tool for the pulmonary evaluation of children with CF.
