Up-to-date Knowledge on the Pathological Diagnosis of Hepatocellular Carcinoma
- Author:
Ji Hae NAHM
1
;
Young Nyun PARK
Author Information
- Publication Type:REVIEW ARTICLE
- From:The Korean Journal of Gastroenterology 2021;78(5):268-283
- CountryRepublic of Korea
- Language:English
- Abstract: Hepatocellular carcinoma (HCC) has heterogeneous molecular and pathological features and biological behavior. Large-scale genetic studies of HCC were accumulated, and a pathological-molecular classification of HCC was proposed. Approximately 35% of HCCs can be classified into distinct histopathological subtypes according to their molecular characteristics. Among recently identified subtypes, macrotrabecular massive HCC, neutrophil-rich HCC, vessels encapsulating tumor clusters HCC, and progenitor phenotype HCC (HCC with CK19 expression) are associated with a poor prognosis, whereas the lymphocyte-rich HCC subtype is related to a better prognosis. This review provides up-to-date knowledge on the pathological diagnosis of HCC according to the updated World Health Organization Classification of Digestive System Tumors 5th ed.
