Comparative study of bone regeneration using fibrin sealant with xenograft in rabbit sinus: pilot study
10.1186/s40902-021-00290-x
- Author:
Won-Hyuk CHOI
1
;
Yong-Deok KIM
;
Jae-Min SONG
;
Sang-Hun SHIN
Author Information
1. Department of Oral and maxillofacial surgery, School of dentistry, Pusan National University, Yangsan 50612, Republic of Korea.
- Publication Type:R E S E A R C H
- From:Maxillofacial Plastic and Reconstructive Surgery
2021;43(1):5-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Stability of the grafted bone volume is one of the important factors to the success of alveolar bone grafts. For this, platelet-rich plasma (PRP) or fibrin sealant is mixed with the bone graft material. Bio-Oss® is a protein-free bovine mineral commonly used in bone graft procedures. The grafting particles are commonly combined with a standard fibrin sealant (Tisseel® ) to fabricate a plastic implantable product. The purpose of this experiment was to evaluate the efficacy of fibrin sealant (Tisseel® ) in bone regeneration performance in a rabbit maxillary sinus model.
Methods:A total of five 3.5 kg weight New Zealand white rabbits were used for the study. After elevating the sinus membrane in both maxillary sinus cavities, Bio-Oss® mixed with normal saline (group 1) was filled into the right side, and Tisseel® mixed Bio-Oss® (group 2) was inserted into the other side. The bone mineral density and bone volume were analyzed with microscopic computed tomography (micro-CT) and histomorphometric 12 weeks after application.
Results:Histologically, new bone formation rate was 14.8%, and grafted bone rate was 70.5% in group 1. In group 2, they were 18.5% and 60.4%, respectively. According to micro-CT analysis, bone mineral density (mg/cm3 , BMD) was 2.5% larger in group 1.
Conclusions:The findings from this study suggest that, although the difference in the bone formation between group 1 and group 2 appears to be insignificant, group 2 had an advantage in using smaller amount of bone substances to achieve the reliable bone formation.
