The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
10.1186/s40902-021-00326-2
- Author:
In-Song LEE
1
;
Jun-Ho CHANG
;
Dae-Won KIM
;
Seong-Gon KIM
;
Tae-Woo KIM
Author Information
1. Department of Orthodontics, School of Dentistry, Seoul National University, Seoul 3080, Republic of Korea.
- Publication Type:R E S E A R C H
- From:Maxillofacial Plastic and Reconstructive Surgery
2021;43(1):39-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol.Method: In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1–100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied.
Results:In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1–100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h).
Conclusion:4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.
