Botulinum toxin A injection into the anterior belly of the digastric muscle increased the posterior width of the maxillary arch in developing rats
10.1186/s40902-019-0203-7
- Author:
Janghoon AHN
1
;
Seong Gon KIM
;
Min Keun KIM
;
Insan JANG
;
Hyun SEOK
Author Information
1. Department of Dentistry, College of Medicine, Hallym University, Chuncheon, 24252 South Korea.
- Publication Type:Original Article
- From:Maxillofacial Plastic and Reconstructive Surgery
2019;41(1):20-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND:The purpose of this study was to evaluate the effects of botulinum toxin A (BTX) injection into the anterior belly of the digastric muscle on a growing rat.
METHODS:Ten Sprague Dawley rats were used in this study. When the rats were 13 days old, 0.5 units of BTX was injected into the anterior belly of the digastric muscle for the experimental group (n = 5). For the control, the same volume of normal saline was injected (n = 5). The rats were sacrificed at 60 days old, and the skulls were harvested for micro-computed tomography (μCT) analysis.
RESULTS:In anthropometric analysis, the zygomatic arch and mandibular bi-condylar width were significantly lower in the experimental group than those in the control group (P = 0.025 and 0.027, respectively). The maxillary point width was significantly higher in the experimental group than that in the control group (P = 0.020).
CONCLUSION:BTX injection into the anterior belly of the digastric muscle had effects on the maxillofacial bony width in growing rats.
