PD-L1 expression correlated with p53 expression in oral squamous cell carcinoma
10.1186/s40902-019-0239-8
- Author:
Itaru TOJYO
1
;
Yukari SHINTANI
;
Takashi NAKANISHI
;
Kenjiro OKAMOTO
;
Yukihiro HIRAISHI
;
Shigeyuki FUJITA
;
Mayu ENAKA
;
Fuyuki SATO
;
Yasuteru MURAGAKI
Author Information
1. Department of Oral and Maxillofacial Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama 641-8509 Japan. kagoky@wakayama-med.ac.jp
- Publication Type:Original Article
- From:Maxillofacial Plastic and Reconstructive Surgery
2019;41(1):56-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND:Programmed cell death ligand 1 (PD-L1) is an immune checkpoint molecule that attenuates the immune response. PD-L1 contributes to failed antitumor immunity; thereby, blockade of PD-L1 with monoclonal antibody enhances the immune response. Recently, it was reported that PD-L1 was regulated by protein 53 (p53). Besides, cytokeratin 17 (CK17) is thought to be a diagnostic marker of oral squamous cell carcinoma (OSCC). Our aim was to evaluate the correlation between the immunohistochemical expression of PD-L1, p53 and CK17 with clinicopathological characteristics and disease-specific survival in patients with OSCC.
METHODS:A total of 48 patients with OSCC were included in this study. Immunohistochemical staining was performed to evaluate the correlation among the expressions of PD-L1, p53 and CK17, and furthermore the correlation among various clinicopathological factors, PD-L1, p53 and CK17.
RESULTS:The positive rate of p53, CK17, PD-L1 (tumor cells) and PD-L1 (tumor-infiltrating lymphocytes) was 63.2%, 91.7%, 48.9% and 57.1%. A statistically significant correlation between p53 expression and T stage and TNM stage (p = 0.049, p = 0.03, respectively) was observed. Also, a statistically significant correlation between p53 and PD-L1 (TCs) expression (p = 0.0009) was observed. Five-year disease-specific survival rate was not significantly correlated with gender, TNM stage, p53 expression, PD-L1 expression and CK17 expression.
CONCLUSION:The expression of p53 and PD-L1 shows significantly positive correlation in oral squamous cell carcinoma in tumor cells. Also, a significant correlation between p53 expression and T stage and TNM stage was observed. No other significant correlation between PD-L1 staining or CK17 and clinical or pathologic characteristics was identified.
