The effects of coenzyme Qâ‚â‚€ supplement on blood lipid indices and hepatic antioxidant defense system in SD rats fed a high cholesterol diet
10.1186/s42826-019-0013-1
- Author:
Ha Na KIM
1
;
Dong Gyung JEON
;
Yong LIM
;
In Surk JANG
Author Information
1. Department of Animal Science and Biotechnology, and the Regional Animal Research Center, Gyeongnam National University of Science and Technology, Chilam-Dong 150, Jinju, Gyeongnam 52725, Korea. isjang@gntech.ac.kr
- Publication Type:Original Article
- From:Laboratory Animal Research
2019;35(2):86-93
- CountryRepublic of Korea
- Language:English
-
Abstract:
A total of 24 SD rats were allotted to four treatment groups such as the control (CON), 1% of cholesterol diet (CHO), 0.5% of coenzyme Qâ‚â‚€ (COQ) and 1% of cholesterol plus 0.5% of coenzyme Qâ‚â‚€ (CHCQ) groups to determine the effects of coenzyme Qâ‚â‚€ (CoQâ‚â‚€) on the antioxidant defense system in rats. The body weight, weight gain, liver weight and abdominal fat pads were unaffected by 0.5% of CoQâ‚â‚€ supplement in the rats. The level of triglyceride and HDL-cholesterol levels in the blood was significantly increased (p< 0.05) by the 1% of cholesterol supplement (CHO), whereas 0.5% of CoQâ‚â‚€ supplement (COQ) did not alter these blood lipid indices. In the mRNA expression, there was a significant effect (P < 0.05) of the CoQâ‚â‚€ supplement on the mRNA expression of superoxide dismutase (SOD), although the mRNA expression of glutathione peroxidase (GPX) and glutathione S-transferase (GST) was unaffected by cholesterol or the CoQâ‚â‚€ supplement. Similar to mRNA expression of SOD, its activity was also significantly increased (P < 0.05) by CoQâ‚â‚€, but not by the cholesterol supplement effect. The activities hepatic GPX and GST were unaffected by CoQâ‚â‚€ and cholesterol supplements in rats. Lipid peroxidation in the CHO group resulted in a significant (p< 0.05) increase compared with that in the other groups, indicating that the CoQâ‚â‚€ supplement to 1% of cholesterol-fed rats alleviated the production of lipid peroxidation in the liver. In conclusion, 0.5% of the CoQâ‚â‚€ supplement resulted in positive effects on the hepatic antioxidant defense system without affecting blood lipid indices in 1% of cholesterol fed rats.
