CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: a case report
10.14405/kjvr.2021.61.e21
- Author:
Sun Woo SHIN
1
;
Yu jin LIM
;
Hyeona BAE
;
Jihu KIM
;
ARom CHO
;
Jinho PARK
;
Dongbin LEE
;
Dong-In JUNG
;
Sang-ki KIM
;
DoHyeon YU
Author Information
1. College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea
- Publication Type:Case Report
- From:Korean Journal of Veterinary Research
2021;61(3):e21-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Canine T-zone lymphoma (TZL) is a mature T-cell lymphoma in dogs. The diagnosis and sub-classification are impossible without biopsy or immunophenotyping by flow cytometry. An 11-year-old, spayed, female Golden Retriever presented with lymph node enlargement. Clinical examination was consistent with canine multicentric lymphoma. However, immunophenotyping revealed positive for CD3, CD4, CD5, CD8, CD21, TCRαβ, and MHCII but negative for CD34, CD45, CD79a, and TCRγδ. Histopathology revealed lymphocytes expanding to the cortex-preserving architecture and thinning of the nodal capsule, and CD3 positive but PAX-5 negative. Owing to the indolent nature of TZL, careful monitoring approach without clinical intervention was utilized.
