Effect of Carteolol Hydrochloride on Sodium-Potassium Activated ATPase in Cattle Lena Epithelial Cell Membrane.
- Author:
Ki Hoon LEE
1
;
We Gon CHANG
;
Byung Nam KANG
Author Information
1. Department of Ophthalmology, Seoul Red Cross Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Active transport;
Na-K ATPase;
Inorganic phosphate;
Carteolol hydrochloride;
Cat aract formation
- MeSH:
Adenosine Triphosphatases*;
Animals;
Biological Transport, Active;
Carteolol*;
Cattle*;
Epithelial Cells*;
Epithelium;
Membranes*;
Ouabain;
Potassium;
Sodium
- From:Journal of the Korean Ophthalmological Society
1990;31(2):207-213
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effect of Carteolol hydrocholride on the Na-K ATPase of anterior capsule and epithelium of cattle lens has been investigated. The experiments were also designed to determine the action of Carteolol hydrochloride on the Na-K ATPase activity in anterior capsule and epithelium of cattle lens. The following results were observed. 1. The predominent location of Na-K ATPase was located in the epithelim and NaK ATPase was closely related with active trasport system of sodium and potassium in the lens epithelium. 2. The activity of Na-K ATPase of cattle lens epithelium was alomst totally inhibited by Ouabain. 3. Beta-adrenergic blocking agent(Carteolol hydrochloride) in the epithelium of cattle lens was shown to be actively transported by the ATPase. 4. The Na-K ATPase activity of cattle lens epithelium was inhibited by Carteolol hydrochloride.
