Statin-Induced Immune-Mediated Necrotizing Myopathy with Anti-HMGCR Antibody
10.46518/kjnmd.2021.13.2.64
- Author:
Jeongjae LEE
1
;
Euihyun KIM
;
Nahee KIM
;
Hyung Jun PARK
;
Yoo Hwan KIM
Author Information
1. Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
- Publication Type:Case Report
- From:
Korean Journal of Neuromuscular Disorders
2021;13(2):64-66
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR) antibody related immune-mediated necrotizing myopathy (IMNM) are usually associated with statin use. The disease has features of persistent muscle weakness and creatine kinase (CK) elevation after statin discontinuation. This report describes a 65-year-old female taking atorvastatin, presenting with both proximal lower extremity weakness. IMNM feature were detected on muscle biopsy and high anti-HMGCR autoantibody titer on enzyme-linked immunosorbent assay (ELISA). This patient was treated with corticosteroid. Muscle weakness and CK are improved after immunosuppressive therapy.
