Clinical Meaning of Neutrophil-to-Lymphocyte Ratio (NLR)in Papillary Thyroid Carcinoma.
10.16956/kjes.2016.16.2.31
- Author:
Yung Il SHIN
1
;
Ja Young CHO
;
Yu Mi LEE
;
Tae Yon SUNG
;
Jong Ho YOON
;
Ki Wook CHUNG
;
Suck Joon HONG
Author Information
1. Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. surgeonckw@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Neutrophil-to-lymphocyte ratio;
Papillary thyroid carcinoma;
Disease-free survival
- MeSH:
Chungcheongnam-do;
Disease-Free Survival;
Follow-Up Studies;
Humans;
Prognosis;
Thyroid Gland*;
Thyroid Neoplasms*;
Thyroidectomy
- From:Korean Journal of Endocrine Surgery
2016;16(2):31-35
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammatory response, which is inexpensive, easily calculated, and known to show correlation with prognosis of cancer. The aim of this study was to evaluate the relationship between NLR and prognosis of papillary thyroid carcinoma. METHODS: A total of 1,142 patients who underwent total thyroidectomy for papillary thyroid carcinoma between 1995~2005 at Asan Medical Center were enrolled in this study. Patients were categorized according to two groups based on NLR and clinico-pathological variables and disease survival were compared between the two groups. RESULTS: Median age of patients was 45.4 years, and the median follow-up period was 48 months. The cut-off value of NLR for prediction of disease-free survival (DFS) was 2. Comparison of DFS between two groups stratified by NLR (NLR ≤2, NLR>2) showed little statistical difference (P=0.48). After adjusting for risk (N stage), there was no significant difference according to N stage (N0: P=0.86, N1a: P=0.4, N1b: P=0.12). CONCLUSION: NLR did not show correlation with disease free survival of papillary thyroid carcinoma.
