Validation of Group B Borderline Resectable Pancreatic Cancer: Retrospective Analysis.
- Author:
Tak Geun OH
1
;
Moon Jae CHUNG
;
Seungmin BANG
;
Seung Woo PARK
;
Jae Bok CHUNG
;
Si Young SONG
;
Jinsil SEONG
;
Chang Moo KANG
;
Woo Jung LEE
;
Jeong Youp PARK
Author Information
- Publication Type:Original Article
- Keywords: Pancreatic neoplasms; Chemoradiotherapy; Chemotherapy; Prognosis
- MeSH: Adenocarcinoma/classification/mortality/pathology/surgery; Adult; Aged; Aged, 80 and over; Chemoradiotherapy; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Pancreatectomy; Pancreatic Neoplasms/*classification/mortality/pathology/*surgery; Retrospective Studies; Treatment Outcome
- From:Gut and Liver 2014;8(5):557-562
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Among borderline resectable pancreatic cancer (BRPC), group B BRPC patients have findings that are suggestive but not diagnostic of metastasis. In this study, we attempted to validate whether group B could truly be categorized as a borderline resectable group. METHODS: We placed the BRPC patients into group A or group B. The survival outcomes were compared between the groups. RESULTS: A total of 53 patients with pancreatic adenocarcinoma was classified as either group A or B borderline resectable. In group A, 23 (60.5%) of 38 patients underwent pancreatectomy after concurrent chemoradiotherapy or chemotherapy, but in group B, only five (33.3%) of 15 patients underwent pancreatectomy, mainly because of the progression of suspected distant metastasis. There was a significant difference in overall survival (OS) between group A and B patients (median OS, 21.2 months vs 10.2 months, respectively; p=0.007). Of the patients who underwent pancreatectomy, group B had a higher recurrence rate compared to group A (recurrence rate: 11 of 23 patients [47.8%] vs five of five patients [100%], respectively; p=0.033). CONCLUSIONS: This report is the first to validate the definition of BPRC. Group B had much worse outcomes, and whether group B BRPC can be categorized as BRPC together with group A is questionable.
