Total Cholesterol Level for Assessing Pancreatic Insufficiency Due to Chronic Pancreatitis.
- Author:
Kenji HIRANO
1
;
Tomotaka SAITO
;
Suguru MIZUNO
;
Minoru TADA
;
Naoki SASAHIRA
;
Hiroyuki ISAYAMA
;
Miho MATSUKAWA
;
Gyotane UMEFUNE
;
Dai AKIYAMA
;
Kei SAITO
;
Shuhei KAWAHATA
;
Naminatsu TAKAHARA
;
Rie UCHINO
;
Tsuyoshi HAMADA
;
Koji MIYABAYASHI
;
Dai MOHRI
;
Takashi SASAKI
;
Hirofumi KOGURE
;
Natsuyo YAMAMOTO
;
Yosuke NAKAI
;
Kazuhiko KOIKE
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Chronic pancreatitis; Pancreatic exocrine insufficiency; Diabetes mellitus; Cholesterol; Cholinesterase
- MeSH: Adult; Aged; Aged, 80 and over; Cholesterol/*blood; Cholinesterases/blood; Diabetes Mellitus, Type 2/complications; Exocrine Pancreatic Insufficiency/*blood/etiology; Female; Follow-Up Studies; Humans; Liver Cirrhosis, Alcoholic/blood; Male; Middle Aged; Nutritional Status; Pancreas/enzymology; Pancreatitis, Alcoholic/blood/complications; Pancreatitis, Chronic/blood/*complications; Serum Albumin/analysis
- From:Gut and Liver 2014;8(5):563-568
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: To determine the nutritional markers important for assessing the degree of pancreatic insufficiency due to chronic pancreatitis in routine clinical practice. METHODS: A total of 137 patients with chronic pancreatitis were followed up for more than 1 year. They were divided into two groups: a pancreatic diabetes mellitus (DM) group, consisting of 47 patients undergoing medical treatment for DM of pancreatic origin, and a nonpancreatic DM group, consisting of 90 other patients (including 86 patients without DM). Serum albumin, prealbumin, total cholesterol, cholinesterase, magnesium, and hemoglobin were compared between the two groups. RESULTS: The total cholesterol was significantly lower in the pancreatic than the nonpancreatic DM group (164 mg/dL vs 183 mg/dL, respectively; p=0.0028). Cholinesterase was significantly lower in the former group (263 U/L vs 291 U/L, respectively; p=0.016). Among the 37 patients with nonalcoholic pancreatitis, there was no difference in the cholinesterase levels between the pancreatic and nonpancreatic (296 U/L vs 304 U/L, respectively; p=0.752) DM groups, although cholesterol levels remained lower in the former (165 mg/dL vs 187 mg/dL, respectively; p=0.052). CONCLUSIONS: Cholinesterase levels are possibly affected by concomitant alcoholic liver injury. The total cholesterol level should be considered when assessing pancreatic insufficiency due to chronic pancreatitis.
