Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea
- Author:
Sukdong YOO
1
;
Min Hyun CHO
;
Hee Sun BAEK
;
Ji Yeon SONG
;
Hye Sun LEE
;
Eun Mi YANG
;
Kee Hwan YOO
;
Su Jin KIM
;
Jae Il SHIN
;
Keum Hwa LEE
;
Tae-Sun HA
;
Kyung Mi JANG
;
Jung Won LEE
;
Kee Hyuck KIM
;
Heeyeon CHO
;
Mee Jeong LEE
;
Jin-Soon SUH
;
Kyoung Hee HAN
;
Hye Sun HYUN
;
Il-Soo HA
;
Hae Il CHEONG
;
Hee Gyung KANG
;
Mee Kyung NAMGOONG
;
Hye-Kyung CHO
;
Jae-Hyuk OH
;
Sang Taek LEE
;
Kyo Sun KIM
;
Joo Hoon LEE
;
Young Seo PARK
;
Seong Heon KIM
Author Information
- Publication Type:Original Article
- From:Kidney Research and Clinical Practice 2021;40(4):673-686
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:The clinical features of pediatric rhabdomyolysis differ from those of the adults with rhabdomyolysis; however, multicenter studies are lacking. This study aimed to investigate the characteristics of pediatric rhabdomyolysis and reveal the risk factors for acute kidney injury (AKI) in such cases.
Methods:This retrospective study analyzed the medical records of children and adolescents diagnosed with rhabdomyolysis at 23 hospitals in South Korea between January 2007 and December 2016.
Results:Among 880 patients, those aged 3 to 5 years old composed the largest subgroup (19.4%), and all age subgroups were predominantly male. The incidence of AKI was 11.3%. Neurological disorders (53%) and infection (44%) were the most common underlying disorder and cause of rhabdomyolysis, respectively. The median age at diagnosis in the AKI subgroup was older than that in the non-AKI subgroup (12.2 years vs. 8.0 years). There were no significant differences in body mass index, myalgia, dark-colored urine, or the number of causal factors between the two AKI-status subgroups. The multivariate logistic regression model indicated that the following factors were independently associated with AKI: multiorgan failure, presence of an underlying disorder, strong positive urine occult blood, increased aspartate aminotransferase and uric acid levels, and reduced calcium levels.
Conclusions:Our study revealed characteristic clinical and laboratory features of rhabdomyolysis in a Korean pediatric population and highlighted the risk factors for AKI in these cases. Our findings will contribute to a greater understanding of pediatric rhabdomyolysis and may enable early intervention against rhabdomyolysis-induced AKI.
