Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome:A Case Report
- Author:
In Na YOON
1
;
Eun Suk CHA
;
Jeoung Hyun KIM
;
Jee Eun LEE
;
Jin CHUNG
Author Information
- Publication Type:Case Report
- From:Journal of the Korean Radiological Society 2022;83(1):246-251
- CountryRepublic of Korea
- Language:English
- Abstract: Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.
