The role of nuclear factor I-C in tooth and bone development.
10.5125/jkaoms.2017.43.2.63
- Author:
Song Yi ROH
1
;
Joo Cheol PARK
Author Information
1. Department of Oral Histology-Developmental Biology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea. jcapark@snu.ac.kr
- Publication Type:Review
- Keywords:
Nuclear factor I-C;
Dentinogenesis;
Osteogenesis;
Osteoporosis
- MeSH:
Animals;
Bone Development*;
Dentinogenesis;
Mesenchymal Stromal Cells;
Mice;
NFI Transcription Factors*;
Odontoblasts;
Osteoblasts;
Osteogenesis;
Osteoporosis;
Tooth*
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2017;43(2):63-69
- CountryRepublic of Korea
- Language:English
-
Abstract:
Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic(-/-) mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert with several factors including transforming growth factor-β1, Krüppel-like factor 4, and β-catenin. This review will focus on the function of NFI-C during tooth and bone formation and on the relevant pathways that involve NFI-C.
