Contrast-Enhanced Ultrasound Parameters in Breast Cancer: Correlations with Prognostic Factors
10.3348/jksr.2019.80.2.318
- Author:
Myoung Eun LEE
1
;
Sung Hun KIM
;
Bong Joo KANG
;
Youn Joo LEE
;
Yunju KIM
Author Information
1. Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
- Publication Type:Original Article
- From:Journal of the Korean Radiological Society
2019;80(2):318-332
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE:To correlate the value of contrast-enhanced ultrasound (CEUS) with prognostic factors of breast cancer.
MATERIALS AND METHODS:24 breast cancer patients were evaluated with CEUS. As a quantitative analysis, the peak enhancement (PE), wash-in and wash-out area under curve (WiWoAUC), wash-in rate (WiR) and wash-out rate, rise time, fall time, mean transit time, time to peak, and wash-in perfusion index (WiPI) were measured. As a qualitative analysis, the enhancement patterns were evaluated. Pathologic prognostic factors, including histologic grade, hormonal receptors and Ki-67 proliferative index were assessed by immunohistochemistry. Correlation of quantitative and qualitative parameters of CEUS with prognostic factors was assessed.
RESULTS:We found that the quantitative CEUS values (PE, WiWoAUC, and WiPI) of estrogen receptor (ER) positive breast cancer were higher than those of ER negative counterpart (all p < 0.05). Lower quantitative CEUS values (PE, WiWoAUC, WiR, and WiPI) were found in triple-negative cancer (TNC) than those of non-TNC (all p < 0.05). No CEUS parameter showed significant difference in distinguishing histologic grade (all p > 0.05).
CONCLUSION:The CEUS parameters were helpful in predicting prognostic factors, such as ER positivity or triple negativity. However, they could not predict the histologic grade.
