The Clinical Usefulness of 99mTc-MIBI Scintimammography in Diagnosis of Breast Cancer.
10.4048/jkbcs.2004.7.1.32
- Author:
Sung Bong YOO
1
;
Woo Chan PARK
;
Hyung Sun SON
;
Hae Myung JEON
;
Jai Hak LEE
Author Information
1. Department of Surgery, College of Medicine, The Catholic University of Korea. wcpark@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
99mTc-MIBI;
Breast cancer;
Diagnosis
- MeSH:
Biopsy;
Breast Neoplasms*;
Breast*;
Diagnosis*;
Female;
Humans;
Mammography;
Needles;
Sensitivity and Specificity;
Ultrasonography
- From:Journal of Korean Breast Cancer Society
2004;7(1):32-36
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Imaging studies for the diagnosis of breast cancer such as ultrasonography or mammography, play an essential role; however, it is well known that they have some limitations; the low specificity of ultrasonography and the low sensitivity of mammography, especially in the dense breasts of Korean women. Recently, 99mTc-MIBI scintimammography was introduced for the detection of breast cancer, and showed acceptable results in its diagnostic accuracy. In this study, the clinical usefulness of 99mTc-MIBI scintimammography was evaluated for the determination of a better imaging study for the diagnosis of breast cancer. METHODS: This study included 75 patients with breast masses, and 3 imaging studies were performed; mammography, ultrasonography and 99mTc-MIBI scintimammography and the results compared on the basis of the pathological reports from core needle or excisional biopsies of the patients. RESULTS: From the pathological reports of 75 patients, 45 cases were confirmed as malignant and 30 as benign diseases. Based on the pathological reports, the sensitivities of mammography, ultrasonography and 99mTc-MIBI scintimammiography were 62.2, 88.9, and 86.7%, and the specificites of 3 imaging studies were 90.0, 76.7, and 90.3% respectively. The positive predictive values were 90.3, 85.1, and 92.9% and the negative predictive values were 61.4, 82.1, and 81.8%, respectively. 99mTc-MIBI mammoscintigraphy showed a comparable sensitivity to ultra-sonography, and a similar specificity to mammography, in the diagnosis of breast cancer. CONCLUSION: Clinically, as a primary imaging tool, 99mTc-MIBI mammoscintigraphy showed acceptable results in the diagnosis of breast cancer. Considering the weak points of ultrasonography and mammography, 99mTc-MIBI mammoscintigraphy would be a very useful tool in the diagnosis of breast cancer.
