Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Management of Cervical Dystonia.
10.5535/arm.2012.36.6.745
- Author:
Han Byul LEE
1
;
Young Sil AN
;
Hyun Young LEE
;
Jee Hyun HWANG
;
Hyun Jung LEE
;
Kil Yong JEONG
;
Jong Woo KIM
;
Shin Young YIM
Author Information
1. The Center for Torticollis, Department of Physical Medicine and Rehabilitation, Ajou University School of Medicine, Suwon 443-749, Korea. syyim@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Cervical dystonia;
18F-Fluorodeoxyglucose;
Positron emission tomography;
Botulinum toxin
- MeSH:
Botulinum Toxins;
Botulinum Toxins, Type A;
Electrons;
Fluorodeoxyglucose F18;
Muscles;
Physical Examination;
Positron-Emission Tomography;
Torticollis
- From:Annals of Rehabilitation Medicine
2012;36(6):745-755
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the management of cervical dystonia (CD) with botulinum toxin type A (BoNT-A) injection. METHOD: Thirty two subjects with CD were included. A BoNT-A injection was provided either by clinically targeting method (group 1) or by 18F-FDG PET/CT-assisted, clinically targeting method (group 2). In group 2, selection of target muscles and dosage of BoNT-A were determined according to the increased 18F-FDG uptake, in addition to physical examination and functional anatomy. The outcomes of BoNT-A injection was compared between the two groups, in terms of the number of subjects who had reinjection before and after 6 months, the number of reinjections, the interval of reinjections, the duration to the minimal Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), the number of adverse events, the reduction rate of TWSTRS at 1-3 months and 3-6 months after injection, and the probability of reinjection-free living. RESULTS: The number of subjects who had reinjection within 6 months was significantly lower in group 2 than in group 1 (10 in group 1 vs. 3 in group 2). The reduction rate of TWSTRS after 3-6 months (37.8+/-15.7% of group 1 vs. 63.3+/-28.0% of group 2) and the probability of reinjection-free living were significantly higher in group 2 than in group 1. CONCLUSION: These findings suggest that 18F-FDG PET/CT study could be useful in management of CD in terms of the identification of dystonic muscles if there is an increase in the 18F-FDG uptake in the cervical muscle of the images.
