TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
- Author:
Anurag MEHTA
1
;
Himanshi DIWAN
;
Divya BANSAL
;
Manoj GUPTA
Author Information
- Publication Type:Case Study
- From:Journal of Pathology and Translational Medicine 2022;56(1):53-56
- CountryRepublic of Korea
- Language:English
- Abstract: SMARCA4/BRG1-deficient lung adenocarcinoma (SD-LUAD) is being recognized as a distinct subtype based on subtle differences in its clinical, morphological, and immunophenotypic attributes compared to other non–small cell lung carcinomas. We present here a case of SD-LUAD with curious thyroid transcription factor 1 (TTF1) expression in a morphologically heterogenous lung adenocarcinoma. The better differentiated area showed preservation of TTF1 expression, and a poorly differentiated tumor had loss of TTF1 expression with universal BRG1 loss.
