Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
- Author:
Thuy Thi LAI
1
;
Yun Joong KIM
;
Hyeo-il MA
;
Young Eun KIM
Author Information
- Publication Type:2
- From:Journal of Movement Disorders 2022;15(1):1-14
- CountryRepublic of Korea
- Language:English
- Abstract: Accumulation of alpha-synuclein (αSyn) protein in neurons is a renowned pathological hallmark of Parkinson’s disease (PD). In addition, accumulating evidence indicates that activated inflammatory responses are involved in the pathogenesis of PD. Thus, achieving a better understanding of the interaction between inflammation and synucleinopathy in relation to the PD process will facilitate the development of promising disease-modifying therapies. In this review, the evidence of inflammation in PD is discussed, and human, animal, and laboratory studies relevant to the relationship between inflammation and αSyn are explored as well as new therapeutic targets associated with this relationship.
