Sentinel lymph Node mapping versus systematic pelvic lymphadenectomy on the prognosis for patients with intermediate-high-risk Endometrial Cancer confined to the uterus before surgery: trial protocol for a non-inferiority randomized controlled trial (SNEC trial)
- Author:
Jun GUAN
1
;
Yu XUE
;
Rong-yu ZANG
;
Ji-hong LIU
;
Jian-qing ZHU
;
Ying ZHENG
;
Bo WANG
;
Hua-ying WANG
;
Xiao-jun CHEN
Author Information
- Publication Type:Clinical Trial Protocol
- From:Journal of Gynecologic Oncology 2021;32(4):e60-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Sentinel lymph node (SLN) mapping has been recommended as an alternative staging approach to lymphadenectomy for apparent uterine-confined endometrial cancer (EC). However, the prognostic value of SLN mapping alone instead of systematic lymphadenectomy on EC patients remains unclear.
Methods:A multi-center, open label, non-inferiority randomized controlled trial has been designed to identify if SLN mapping alone is not inferior to pelvic lymphadenectomy on prognosis of patients with intermediate-high-risk EC clinically confined to uterus. Eligible patients will be 1:1 randomly assigned to accept SLN mapping or pelvic lymphadenectomy. The primary endpoint is the 2-year progression-free survival (PFS). The second points are the 5-year PFS, 5-year overall survival, surgery-related adverse events and life quality. A total of 780 patients will be enrolled from 6 hospitals in China within 3-year period and followed up for 5 years.
