Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Helicobacter pylori Eradication: a Case Report
- Author:
Keitaro TAKAHASHI
1
;
Nobuhiro UENO
;
Takahiro SASAKI
;
Yu KOBAYASHI
;
Yuya SUGIYAMA
;
Yuki MURAKAMI
;
Takehito KUNOGI
;
Katsuyoshi ANDO
;
Shin KASHIMA
;
Kentaro MORIICHI
;
Hiroki TANABE
;
Yuki KAMIKOKURA
;
Sayaka YUZAWA
;
Mishie TANINO
;
Toshikatsu OKUMURA
;
Mikihiro FUJIYA
Author Information
- Publication Type:Case Report
- From:Journal of Gastric Cancer 2021;21(1):103-109
- CountryRepublic of Korea
- Language:English
- Abstract: Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of Helicobacter pylori and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after H. pylori eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before H. pylori eradication to 0-IIa+IIc and then 0-I after H. pylori eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by H. pylori eradication.
