Gastric Plexiform Fibromyxoma with Two Different Growth Patterns on Histological Images: a Case Report
- Author:
Zhenyu LI
1
;
Qingming JIANG
;
Dongfang GUO
;
Yangling PENG
;
Jing ZHANG
;
Xinyu CHEN
Author Information
- Publication Type:Case Report
- From:Journal of Gastric Cancer 2021;21(2):213-219
- CountryRepublic of Korea
- Language:English
- Abstract: Plexiform fibromyxoma (PF) of the stomach is a very rare mesenchymal tumor of the gastrointestinal tract. We report the first case of PF with 2 different growth patterns pathologically confirmed after surgical resection. The tumor was characterized microscopically as infiltrative; it demonstrated diffuse growth into the smooth muscle bundles of the muscularis propria and was also multinodular and plexiform within the myxoid stroma.Immunohistochemical analysis revealed that the tumor cells were positive or weakly positive for smooth muscle actin, vimentin, and H-caldesmon and negative for desmin, CD117, CD34, CK-20, Pan-CK, Dog1, S100, ER, PR, and CD10. No mutations of C-kit and platelet-derived growth factor receptor alpha were detected. No genetic disruption of glioma-associated oncogene homolog 1 was detected by fluorescence in situ hybridization. The final diagnosis of PF was mainly based on the morphological and immunohistochemical findings.
