An Immunohistochemical Study of Molluscum Contagiosum.
- Author:
Ho Seok SUH
;
Jee Ho CHOI
;
Kyung Jeh SUNG
;
Jai Kyoung KOH
- Publication Type:Original Article
- Keywords:
Molluscum Conteigiosum;
EGF Receptor;
Immunohistochenica Stain
- MeSH:
Dermis;
Epidermal Growth Factor;
Epidermis;
Factor XIIIa;
HLA-DR Antigens;
Humans;
Hyperplasia;
Keratinocytes;
Langerhans Cells;
Molluscum Contagiosum*;
Mucous Membrane;
Poxviridae;
Receptor, Epidermal Growth Factor;
S100 Proteins;
Skin
- From:Korean Journal of Dermatology
1994;32(5):787-794
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Molluscum contagiosum is a common viral infect oudisease of the skin and mucous membrane that is caused by a molluscum contagiosum virus(MCV; which belongs to the poxviridae family. One of the characteristic histopathologic findings is an epidermal hyperplasia Porter and Archard reported that this phenomenon might be explained by a virus induced epidermal growth factor (EGF) like polypeptide. There was a report that epidermal prolifeation in viral infection might be modulated by other factors than the virus itself such as local immune response. OBJECTIVE: The purpose of this study was to examine the expression pattern of epidermal growth factor receptor and other immunocompetent cells by immunohistochemical stainings. METHOD : We performed iinmunoperoxidase staining on the 11 slaecmens of formalin-fixed, paraffin-embedded molluscum lesions and 15 specimens of snap frozen mollucum lesions with nine primary antibodies(EGFR, factor XIIIa, CDla, S-100 protein, MAC 387, HLA-IR, CD4, CDS, L26) RESULTS: EGF receptors were strongly expressed in lesional MCV ifect,ed keratinocytes. The number of CDla and factor XIIIa positive dermal dendritic cells were sigtly increased. In inflamed lesions, CD4 and HLA-DR expressions were increased in the dermis and per lesional epidermis. CONCLUSION: This study shows that 1) increased EGFR expression is of MCV infected keratinocytes may be related to the pathogenesis of epidermal hyperplasia. 2) helper T lyrnphocytes may operate in inflamed molluscum lesions.
