A Case Of D-Penicillamine Induced Polymyositis.
- Author:
Seung Young KIM
1
;
Tae Hwan KIM
;
Pyoung Nam KIM
;
Jae Bum JUN
;
Sung Soo JUNG
;
In Hong LEE
;
Sang Cheol BAE
;
Dae Hyun YOO
;
Seong Yoon KIM
Author Information
1. Rheumatism Center, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
D-Penicillamine;
Polymyositis
- MeSH:
Arthritis, Rheumatoid;
Biopsy;
Diagnosis;
Female;
Humans;
Middle Aged;
Muscular Diseases;
Myositis;
Penicillamine*;
Polymyositis*
- From:The Journal of the Korean Rheumatism Association
1995;2(1):87-91
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Polymyositis can develop infrequently as one of the autoimmune complications of D-penicillamine treatment, but its exact pathogenesis remains unclear. Suspicion of D-penicillamine induced polymyositis should be followed by immediate drug withdrawal and confirmation of diagnosis by determination of muscle enzymes, EMG and biopsy. Most patients recover from polymyositis completely within 6 months after drug withdrawal, even though steroid may be used in severe conditions. Suspicion of pre-existing low-grade myopathy or myositis should possibly be regarded as a relative contraindication to D-penicillamine treatment and analysis of muscle enzymes should be followed regularly. We experienced a case of rheumatoid arthritis who developed polymyositis after treatment of D-penicillamine for about 5 weeks(total dosage 3500mg) in a 47-year-old female and report this with a review of literature.
