Clearance of Actinic Keratosis Caused by the Prodrug of 5-Fluorouracil.
- Author:
In Ho PARK
1
;
Sang Min HWANG
;
Sung Ku AN
Author Information
1. Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
- Publication Type:Case Report
- Keywords:
5-fluorouracil;
Actinic keratosis
- MeSH:
Actins*;
Drug Therapy;
Fluorouracil*;
Humans;
Hypersensitivity;
Inflammation;
Keratosis, Actinic*;
Stomach;
Tegafur
- From:Korean Journal of Dermatology
1999;37(10):1528-1531
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Tegafur [1-(tetrahydro-2-furyl)-5-fluorouracil], the prodrug of 5-fluorouracil, is an anticancer agent. Several cutaneous reactions have been reported following systemic 5-fluorouracil for the treatment of malignancies. We report a patient with marked inflammation of the actinic keratosis following the use of tegafur for stomach carcinoma. The side-effect with 5-fluorouracil was beneficial as most actinic keratosis cleared following the inflammatory reaction. Dermatologists and oncologists should be aware of this potential side-effect, not only because it may become more prevalent but, most importantly, because it is not an allergic reaction to 5-fluorouracil but a dose-dependent response, and the chemotherapy may be continued in most patients.
