Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice
- Author:
Sung Eun WANG
1
;
Seung Yeon KO
;
Yong Seok KIM
;
Sungsin JO
;
Seung Hoon LEE
;
Sung Jun JUNG
;
Hyeon SON
Author Information
- Publication Type:Original Article
- From:Experimental & Molecular Medicine 2018;50(3):e455-
- CountryRepublic of Korea
- Language:English
- Abstract: Transient receptor potential vanilloid 1 (TRPV1) affects mood and neuroplasticity in the brain, where its role is poorly understood. In the present study we investigated whether capsaicin (8-methyl-N-vanillyl-trans-6-nonenamide), an agonist of TRPV1, induced chromatin remodeling and thereby altered gene expression related to synaptic plasticity. We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters. Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression. Taken together, our findings implicate HDAC2 in capsaicin-induced transcriptional regulation of synaptic molecules and support the view that HDAC2 is a molecular link between TRPV1 activity and synaptic plasticity.
