The Total Antioxidant Capacity According to the Diet and the Life Style in Patients with the Chronic Cardiovascular Disease.
- Author:
Yoon Jong CHANG
1
;
Kyung Eun SONG
;
Wee Hyun PARK
;
Young Sun CHOI
;
Nan hee LEE
Author Information
1. Department of Clinical Pathology, Kyungpook National University School of Medicine, Korea
- Publication Type:Original Article
- Keywords:
Antioxidants;
Cardiovascular disease;
Total antioxidant status
- MeSH:
Alcohol Drinking;
Antioxidants;
Cardiovascular Diseases*;
Cholesterol;
Chromatography, Liquid;
Defense Mechanisms;
Diet*;
Free Radicals;
Humans;
Life Style*;
Lipoprotein(a);
Lipoproteins;
Metabolism;
Oxidative Stress;
Triglycerides;
Vitamin A;
Vitamins
- From:Korean Journal of Clinical Pathology
1999;19(5):504-509
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Decreased antioxidant defense mechanisms and over-generated free radicals by either normal or aberrant metabolism play an important role in the pathogenesis of cardiovascular disease and cancer. And the life style and diet including antioxidant vitamin A and E have been thought an important factor in antioxidant systems. Recently, Total Antioxidant Status kit (TAS; Randox, UK) has been developed for measuring the total antioxidant capacity of blood. So we evaluated the association of life style and total antioxidant capacity in patients with chronic cardiovascular disease. METHODS: Sixty six cases of chronic cardiovascular disease and sixty three normal controls were evaluated. Serum total antioxidant capacity was measured by Hitachi 747 (Hitachi Ltd, Japan) with TAS kit, vitamin A and E were measured by high performance liquid chromatography method, and serum lipid profile by Hitachi 7060 (Hitachi Ltd, Japan). RESULTS: The mean total antioxidant capacity did not show difference between patients and controls. After 3 months, we detected significant increase of total antioxidant capacity, high-density lipoprotein cholesterol and mild increase of antioxidant vitamins and significant decrease of total cholesterol, triglyceride, lipoprotein (a). The heavy alcohol consumption group showed significant difference with other groups (P<0.05). CONCLUSIONS: The measurement of total antioxidant capacity for the cardiovascular disease patients was thought to be useful to evaluate oxidative stress and antioxidant status. Alcohol consumption and supplementation with antioxidant vitamins could have an effect on total antioxidant capacity.
