Severe Hypophosphatemia-Induced Acute Toxic-Metabolic Encephalopathy in Continuous Renal Replacement Therapy
- Author:
Sun Ae HAN
1
;
Ha Yeol PARK
;
Hyun Woo KIM
;
Jong In CHOI
;
Da Yeong KANG
;
Hyun Lee KIM
;
Jong Hoon CHUNG
;
Byung Chul SHIN
Author Information
- Publication Type:Case Report
- From:Electrolytes & Blood Pressure 2019;17(2):62-65
- CountryRepublic of Korea
- Language:English
- Abstract: Acute toxic-metabolic encephalopathy (TME) is an acute condition of global cerebral dysfunction in the absence of primary structural brain disease. Severe hypophosphatemia leads to muscle weakness and involves the diaphragm but hypophosphatemia-induced TME is very rare. Herein, we report the case of a 43-year-old woman with encephalopathy with severe hypophosphatemia during continuous renal replacement therapy. She presented with features of oliguric acute kidney injury on diabetic kidney disease due to volume depletion. At admission, her mental status was alert but gradually changed to stupor mentation during continuous renal replacement therapy. Her phosphate level was less than 0.41 mEq/L and Glasgow coma scale decreased from 15 to 5. After phosphate intravenous replacement and administration of phosphate-containing replacement solution, the phosphate level increased to 2.97 mEq/L and mental state returned to alert state. This case demonstrates that the level of phosphorus should be observed during continuous renal replacement therapy.
