Association Between Body Mass Index and Cognitive Function in Mild Cognitive Impairment Regardless of APOE ε4 Status
10.12779/dnd.2022.21.1.30
- Author:
Ye Sol MUN
1
;
Hee Kyung PARK
;
Jihee KIM
;
Jiyoung YEOM
;
Geon Ha KIM
;
Min Young CHUN
;
Hye Ah LEE
;
Soo Jin YOON
;
Kyung Won PARK
;
Eun-Joo KIM
;
Bora YOON
;
Jae-Won JANG
;
Jin Yong HONG
;
Seong Hye CHOI
;
Jee Hyang JEONG
Author Information
1. Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea
- Publication Type:Original Article
- From:Dementia and Neurocognitive Disorders
2022;21(1):30-41
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:and Purpose: In this study we aimed to find the association between neuropsychological performance and body mass index (BMI) in patients with mild cognitive impairment (MCI). In addition, we investigated the effects of the apolipoprotein E (APOE) genotype in the relationship between the BMI and cognition in MCI.
Methods:We enrolled a cohort of 3,038 subjects with MCI aged 65–90 from the Clinical Research Center for Dementia of South Korea and a dementia cohort of the Ewha Womans University Mokdong Hospital. MCI patients were classified into three subgroups according to the Asian standard of BMI. We compared cognitive performances between groups by one-way analysis of variance. To investigate the effects of the APOE genotype, we used multivariate linear regression models after adjusting for possible confounders.
Results:Even though normal BMI groups were younger, had more females, and had less comorbidities, the higher BMI groups had better cognitive functions. Among subjects with APOE ε4 carriers, there was a positive relationship between the BMI and the memory task alone.
Conclusions:Our findings suggested that higher BMI in patients with MCI were associated with better cognitive performance. The effects of the APOE ε4 genotype in the associations between BMI and cognition were distinguishing. Therefore, according to physical status, APOE ε4 genotype-specific strategies in the assessments and treatments may be necessary in elderly patients with MCI.
