Alteration in Cngb1 Expression upon Maternal Immune Activation in a Mouse Model and Its Possible Association with Schizophrenia Susceptibility
10.9758/cpn.2021.19.4.618
- Author:
Hwayoung LEE
1
;
Sung Wook KANG
;
Hyeonjung JEONG
;
Jun-Tack KWON
;
Young Ock KIM
;
Hak-Jae KIM
Author Information
1. Department of Clinical Pharmacology, Soonchunhyang University College of Medicine, Cheonan, Korea
- Publication Type:Original Article
- From:Clinical Psychopharmacology and Neuroscience
2021;19(4):618-627
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:The cyclic nucleotide-gated channel (Cng) regulates synaptic efficacy in brain neurons by modulating Ca2＋ levels in response to changes in cyclic nucleotide concentrations. This study investigated whether the expression of Cng channel, cyclic nucleotide-gated channel subunit beta 1 (Cngb1) exhibited any relationship with the pathophysiology of schizophrenia in an animal model and whether genetic polymorphisms of the human gene were associated with the progression of schizophrenia in a Korean population.
Methods:We investigated whether Cngb1 expression was related to psychiatric disorders in a mouse model of schizophrenia induced by maternal immune activation. A case-control study was conducted of 275 schizophrenia patients and 410 controls with single-nucleotide polymorphisms (SNPs) in the 5′-near region of CNGB1.
Results:Cngb1 expression was decreased in the prefrontal cortex in the mouse model. Furthermore, the genotype frequency of a SNP (rs3756314) of CNGB1 was associated with the risk of schizophrenia.
Conclusion:Our results suggest that CNGB1 might be associated with schizophrenia susceptibility and maternal immune activation. Consequently, it is hypothesized that CNGB1 may be involved in the pathophysiology of schizophrenia.
