Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series
10.9758/cpn.2021.19.4.789
- Author:
Cheng-Chen CHANG
1
;
Yen-Jen CHEN
;
Yu-An CHEN
;
Yi-Cheng LIAO
Author Information
1. Department of Psychiatry, Changhua Christian Hospital, Changhua, Taiwan
- Publication Type:Case Report
- From:Clinical Psychopharmacology and Neuroscience
2021;19(4):789-792
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 older female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the older women taking antidepressants would be of benefits.
